Promising results from an initial clinical trial show that sodium ascorbate – a pH-balanced formulation of vitamin C – is effective in treating sepsis.
Thank you for pointing this out. Saw the headline and was like, not this vitamin c crap again. So many trials have failed for this, critical care just seems obsessed with the idea and will not give it up. I agree their end points are very unconvincing. The group treated in addition to increased urine output had some kind of induced hypernatremia. Would need more info to be sure, but all this says to me is they probably caused some sort of mild diuretic effect.
I think it’s just an effect of giving them sodium ascorbate instead of ascorbic acid. It’s not the usual cause of hypernatremia, but it is possible to cause hypernatremia with that high a level of sodium intake, especially in the setting of kidney failure. I think they knew that and that’s why they specifically noted that side effect.
Thank you for pointing this out. Saw the headline and was like, not this vitamin c crap again. So many trials have failed for this, critical care just seems obsessed with the idea and will not give it up. I agree their end points are very unconvincing. The group treated in addition to increased urine output had some kind of induced hypernatremia. Would need more info to be sure, but all this says to me is they probably caused some sort of mild diuretic effect.
I think it’s just an effect of giving them sodium ascorbate instead of ascorbic acid. It’s not the usual cause of hypernatremia, but it is possible to cause hypernatremia with that high a level of sodium intake, especially in the setting of kidney failure. I think they knew that and that’s why they specifically noted that side effect.