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Less poisonous. Its purpose is to be poison.
If poison expires it becomes safer
If medicine expires it becomes poison
In the case of tetracycline antibiotics the degradation products can damage the kidneys and cause Fanconi syndrome. So in that case as a medicine for people it becomes poison, as a poison for bacteria it becomes safer.
Not necessarily.
Aspirin yes, paracetamol no.
Some medicine also just becomes less effective, not more dangerous.
Surely it’d be less effective since some of the molecules or whatever have broken down into (hopefully) less poisonous molecules?