Are you talking about internal hubs? There are many bikes with internal hubs available in the US, far more than bikes with Pinions. Even department/sports stores like REI sell bikes with internal hubs. I have 4 bikes with internal hubs, one is a CVT which is a hoot to shift but heavy as heck.

So abused kids grow up to have smaller hippocampi, but not every person with a small hippocampus also has major depression?

I’m gonna be really shallow and judgmental and just say her picture is creepy, too. What a bizarre pose and expression.

This is the cool part:

But histotripsy foils cancer’s cloaking efforts by destroying its cell walls, leaving the tumor antigens in plain sight for the body’s immune system.

This effect was detailed in a pair of papers published by the U-M research team between March 2022 and January 2023. They demonstrate that the sound waves used to break down cancerous tumors in rats also helped trigger the rats’ immune response. After histotripsy destroyed 50% to 75% of liver tumor volume, the rats’ immune systems cleared away the rest, with no evidence of recurrence or metastases in more than 80% of animals.

That immune response occurred throughout the body, not just in areas targeted by the histotripsy treatment, resulting in the reduction of tumors far from the treated area.

The immune response is key. Without it, histotripsy is just yet another way to destroy a tumor without curing the cancer.

There have been similar studies looking at “feeding” mannose to solid tumors. The starve-the-tumor-with-fake-nutrients option has a lot of potential.

Coffee makes me incredibly hungry (any caffeine does). This would backfire on me soooooo bad.

I have to wonder if an extra cup of any liquid per day would help avoid weight gain. You hear so much about people misinterpreting thirst as hunger - they eat instead of drinking.

You can add pockets to the pants you buy, too. This video by Morgan Donner is adding several examples of types of pockets to skirts, but the process is the same. https://www.youtube.com/watch?v=7pE_nrHKd58

And there’s this one by Bernadette Banner https://www.youtube.com/watch?v=thlzJj1EHiY

Thigh pockets are really great for phones. You can make visible patch pockets or subtle welt pockets and you can customize to the size of your phone.

300+ days a year of sunshine, all they need to do next is pop some solar panels up on those roofs!

You can rent a furnished studio short-term for 2 days minimum at $99/day, and you get the same transportation benefits as residents do during your stay. Honestly, I’m considering this for a vacation during the winter. This walkable community idea is fascinating to me and I want to check it out. https://culdesac.com/

And I am very grateful for that. I deeply appreciate this policy.

Thanks, all you awesome admins!

For t shirts I always sing the praises of Gettees. Tiny “factory” of half a dozen people making extraordinarily high quality and durable shirts in Detroit. Most of the people doing the sewing are former auto upholstery stitchers from the car factories. The quality is truly the best I’ve ever encountered. https://gettees.us/

Side note about pockets: Duluth Trading women’s pants have multiple ginormous pockets, and about half have crotch gussets or anterior inseams to avoid chub-rub destroying the pants.

A “final solution”, as it were.

I read it as being at least one of the three.

That’s how I read the ol’ saying, too. Unless at least one of those things applies, maybe reconsider the post.

This is cool. I always wondered why I can instantly grasp 1 through 4, but 5 and up become abstract. Thank you for posting this!

A good place to start on YouTube is Bernadette Banner’s channel. She is a clothing historian, so there’s a lot of historical and historical recreation stuff, but she also has a few basic repair and tailoring techniques videos. She wrote a mending book that I hear is much more in-depth than her videos (I haven’t read it). https://www.barnesandnoble.com/w/make-sew-and-mend-bernadette-banner/1139915226

Patagonia Wornwear has a lot of repair instructions for outdoor gear (you don’t have to buy their repair materials). https://wornwear.patagonia.com/repairs

Reddit “visiblemending” and “invisiblemending” are also very good resources.

There is a generation of little old ladies who are passionate about sewing, but have no-one to sew for. Their kids are grown, and their grandkids don’t want handmade clothes. Ask at a senior center or at a local (not chain) fabric shop, seek out one of these ladies and hire her to sew for you. Or barter: help her around the house or garden or drive her to appointments or to get groceries, and in exchange she sews clothes from fabrics and patterns you choose. Or tailors used clothes to make them fit you better, or mends your worn clothes, etc.

Here’s an excellent place to start: https://tincanknits.com/collection/the-simple-collection

And “run” the heels and ball of the foot so they felt down and last longer: https://www.youtube.com/watch?v=4fKKLOUNOHU

I did a deep-dive reading and watching videos learning about sturdy and long-lasting fabrics and materials. Learned a bit about tailoring for durability, too. (For example, Duluth Trading shifted the inseams on their Firehose pants forward. The forward seams don’t rub on each other when you walk, and so the inner thighs don’t self-destruct as quickly.)

There are also a ton of excellent resources on how to mend clothing and properly care for it. And it doesn’t take much effort, really.

So now I have a bunch of older clothes, with subtle repairs, still in good shape. Sure, I’d like some sexy new trendy disposable stuff so I can be one of the cool kids - but that’s how fast fashion gets its claws into you. Preying on our magpie-like desires for shiny new things makes somebody big bucks. (And creates huge waste and exploits desperate workers.)

Buy sturdy “classic” clothes. Keep them in good repair. Fight the system.

Yep, it will be free for California residents in need, and much cheaper for everyone else. Pharma corps have been running amok raising insulin costs insane amounts. California can make their own and provide it directly to residents for far less money than they spend buying it from the companies.