Exercise has both long and short term effects on glucose, 1. upregulates insulin receptor production, 2. fires off receptors on muscles to haul the glucose out of the blood and into the muscles for immediate use, and for storage as glycogen (stacks of glucose). And there’s a lot more being looked at in this paper, and for that matter more going on in exercise effects on tumors than just glucose regulation, tho’ it is an important piece.

Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle–tumor metabolic competition https://www.pnas.org/doi/10.1073/pnas.2508707122

Significance It is well established from both preclinical and clinical studies that exercise protects against tumor growth and progression. However, the biomarkers of this beneficial effect are not well delineated. Here, we demonstrate using stable isotope tracer methodology and unbiased metabolomics analyses that aerobic exercise induces glucose repartitioning in rodents with breast cancer and melanoma. We further demonstrate that fitness—which can be measured along a continuum, beyond the binary “exercise/no exercise” paradigm that may not translate well to humans in practice—is a key predictor of tumor metabolism. These data highlight the importance of a nuanced, systemic view of the metabolic effects of exercise in cancer. Abstract Higher exercise capacity and regular exercise training improve cancer prognosis at all stages of disease. However, the metabolic adaptations to aerobic exercise training that mediate tumor–host interactions are poorly understood. Here, we demonstrate that voluntary wheel running slows tumor growth and repartitions glucose uptake and oxidation to skeletal and cardiac muscle and away from breast and melanoma tumors in mice. Further, prehabilitation induces repartitioning of glucose metabolism in obese mice: Uptake and oxidation of glucose are enhanced in skeletal and cardiac muscle, and reduced in tumors. These increases in muscle glucose metabolism and reductions in tumor glucose metabolism, correlated with slower tumor progression. Using [U-13C6] glucose infusion, we show that exercise increases the fractional contribution of glucose to oxidative metabolism in muscle while reducing it in tumors, suggesting that aerobic exercise shifts systemic glucose metabolism away from the tumor microenvironment and toward metabolically active tissues. Transcriptional analysis revealed downregulation of mTOR signaling in tumors from exercised mice. Collectively, our findings suggest that voluntary exercise may suppress tumor progression by enhancing host tissue glucose oxidation and limiting tumor glucose availability, supporting a model in which exercise-induced metabolic competition constrains tumor energetics.

One of my favorite, and most quoted XKCD! Makes learning exciting!

Yep, in elementary school. Gah! We were just kids. Also love jazz to this day and beyond. Haven’t had interest in square dancing since childhood.

History is important. And many may not be aware of Ford’s associations with Hitler and Nazi-ism.

disgusting weirdo.

Here’s 2 suggestions for action:

1. Add your signature to this petition and promote it amongst your peeps : https://act.weareultraviolet.org/sign/no-fundraisers-for-killers/

2. January 20, 2pm nation wide walk out. 3pm show up at your representatives office, and discuss why Noem should be impeached, including MN in the investigation of the murder perpetrated by Jonathon Ross, and other timely matters.

Unvoiced suggestions are less even than wishes.

See ya there, my friend.

True, it is a valid concern. Have you any suggestions?

I guess we should just quit, not even bother to try. Is that what you are suggesting?

Do you always give up so easily? By the way in English it’s “Our Representatives don’t care what their constituents want.” It’s funny to me how many trolly folks there are around here, posting discouraging nonsense. Have a nice day.

So we should give up, dig a hole and stick your heads in? I’m not a giving up sort of person. But if that’s your preference, go for it. smh

Contact your representatives, assure this bill goes no where.

So the grants must be reinstated.

The cost of DOGE, and the rest of this administration to the US and indeed world economy is astronomical.

Any thing to keep our collective spirits up in these troubling times.

Bunch of fascist losers. smh.

Because the aren’t really ice, the solid form of water. And water in whatever form doesn’t give a shit about your credentials, nor your ignorance of basic physics.

Epstein Island

I’m pretty sure the charge is 1st degree murder, however ‘premeditation’ is the key point of differentiation between 1st and 2nd degree.

Here’s what I found from Minnesota Statutes Section 609.185: https://legalclarity.org/understanding-murder-charges-and-penalties-in-minnesota/

"In Minnesota, the criteria for murder charges are defined by state statutes, which outline the circumstances and intent required for each degree. Minnesota Statutes Section 609.185 outlines conditions for first-degree murder, including premeditated intent to kill, killing during certain felonies, or causing the death of a peace officer. Proving intent and premeditation is pivotal in distinguishing first-degree murder from other charges.

Second-degree murder, under Minnesota Statutes Section 609.19, involves intentional killing without premeditation or causing death while committing a felony not specified for first-degree murder. The absence of premeditation differentiates it from first-degree murder, yet intent remains crucial. This distinction highlights the importance of the defendant’s state of mind.

Third-degree murder, detailed in Minnesota Statutes Section 609.195, is characterized by acts that are dangerous to others and demonstrate a depraved mind, without regard for human life, but without intent to kill any particular person. This charge often applies when actions were reckless or negligent, leading to death. The focus is on the reckless nature of the act rather than specific intent to kill, differentiating it from higher degrees of murder."

It was actually 50, but some news sources are saying 100 for their own reasons.

The Danes have already stated, “shoot first, ask questions later.” I don’t expect them to step down from that position. An invasion by a hostile state IS an act of war. And the invader is by definition a war criminal. The Danes are being serious, they aren’t jesting. FAFO.